Edit |   |
---|---|
Antigenic Specificity | ADRB2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | mouse, rat, bovine, dog, sheep |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Recognizes endogenous levels of Beta-2 Adrenergic Receptor protein. ADRB2 is directly associated with one of its ultimate effectors, the class C L-type calcium channel CaV1.2. This receptor-channel complex is coupled to the Gs G protein, which activates adenylyl cyclase, catalysing the formation of cyclic adenosine monophosphate (cAMP) which then activates protein kinase A, and the counterbalancing phosphatase PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling. A two-state biophysical and molecular model has been proposed to account for the pH and REDOX sensitivity of this and other GPCRs. |
Immunogen | Immunogen: ADRB2 antibody was raised in Rabbit using a KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Beta-2 Adrenergic Receptor as the immunogen |
Other Names | [Purified ADRB2; ADRB2; ADRB2; ADRB2R; B2AR; Beta-2 adrenergic receptor; Beta-2 adrenoreceptor; Beta-2 adrenoceptor] |
Gene, Accession # | [ADRB2] |
Catalog # | MBS5316052 |
Price | $270 |
Order / More Info | ADRB2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |