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Antigenic Specificity | TRIB3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein G purified |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. Can inhibit APOBEC3A editing of nuclear DNA. |
Immunogen | Immunogen: Recombinant human Tribbles homolog 3 protein (152-325AA) |
Other Names | [Tribbles homolog 3TRB-3; Neuronal cell death-inducible putative kinase; SINK; p65-interacting inhibitor of NF-kappa-B; TRIB3; C20orf97; NIPK; SKIP3; TRB3] |
Gene, Accession # | [TRIB3], Gene ID: 57761, NCBI: NP_001288117.1, UniProt: Q96RU7 |
Catalog # | MBS7050899 |
Price | $160, $235 |
Order / More Info | TRIB3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |