NCC Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-NCC antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | NCC |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat, dog |
| Isotype | n/a |
| Format | Protein A purified |
| Size | 0.1 mg |
| Concentration | 1mg/mL |
| Applications | Western Blot(WB), Immuhistochemistry (IHC), Immunocytochemistry/Immunofluorescence (ICC/IF), IEM |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Detects~160 kDa. Background Info: Detects ~160kDa Scientific Background: NCC, a thiazide-sensitive NaCl co-transporter, is found on the apical membrane of the distal convoluted tubule, where it is the principal mediator of Na and Cl- reabsorption in this segment of the nephron. It is activated by phosphorylation, and has been implicated in renal NaCl and K homeostasis (1). Regulation of NCC expression and phosphorylation by dietary NACl restriction appears to involve SGK1(1). In experiments with angiotensin II-infused mice, increased sensitivity to Ang II may involved over-activity of NCC (2). Therefore, NCC is the target of thiazide diuretics used in the treatment of hypertension (1). Molecular experiments have also shown that NCC has been |
| Immunogen | Immunogen: Produced against a synthetic peptide mapping to a segment of rat NCC (amino acids 74-95), N-terminal. |
| Other Names | [SLC12A3, SCYL1,CKb10, MCP- 4, MGC17134, NCC - 1, NCC1, SCYA13, CK -beta -10, monocyte chemoattractant protein 4, monocyte chemotactic protein 4, new CC chemokine 1, small inducible cytokine A13, small inducible cytokine subfamily A (Cys -Cys) member 13, chemokine (C - C)], [SLC12A3; Slc12a3; NCC; TSC; NCCT; Tsc] |
| Gene, Accession # | Gene ID: 6559, NCBI: NP_000330, UniProt: P55018 |
| Catalog # | MBS805073 |
| Price | $400 |
| Order / More Info | NCC Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Vallon V., Schroth J, Lang F, Kuhl D and Uchida S. (2009) Am J Physiol Renal Physiol. 297(3): F704-712. 2. Tiwari S., et al. (2009) Am J Nephrol. 30(6): 554-562. 3. Chee K.N., Vorontsova I., Lim J.C., Kistler J. and Donaldson P.J. (2010) Mol Vis. 16:800-812. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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