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Antigenic Specificity | MAGI3 (C-Term) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | unconjugated |
Size | 0.05 mL, 0.2 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This MAGI3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1330-1360 amino acids from human MAGI3. Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2. |
Immunogen | n/a |
Other Names | [Purified Rabbit (Pab); Membrane-associated guanylate kinase; WW and PDZ domain-containing protein 3; Membrane-associated guanylate kinase inverted 3; MAGI-3; MAGI3; KIAA1634] |
Gene, Accession # | [MAGI3], Gene ID: 260425, NCBI: NP_001136254.1, UniProt: Q5TCQ9 |
Catalog # | MBS9215751 |
Price | $165, $370 |
Order / More Info | MAGI3 (C-Term) Antibody from MYBIOSOURCE INC. |
Product Specific References | Wu Y.,et al.J. Biol. Chem. 275:21477-21485(2000).Franklin J.L.,et al.Exp. Cell Res. 303:457-470(2005).Gregory S.G.,et al.Nature 441:315-321(2006).Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.Nagase T.,et al.DNA Res. 7:273-281(2000). |