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Antigenic Specificity | NOD1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total NOD1 protein. Nod1/CARD4 is a cytosolic protein structually related to Apaf-1 and plant drug-resistance proteins that has been implicated in apoptosis and inflammatory responses to certain pathogenic bacteria (1-3). It contains an amino-terminal caspase recruitment domain (CARD) that is linked to a central nucleotide-binding domain (NBD; also known as a NOD domain) and is followed by carboxy-terminal leucine-rich repeats (LRR) (1). Like Apaf-1, Nod1 induces apoptosis by a CARD/NBD-dependent activation of caspase-9 (1). The primary function of Nod1 is thought to be as a sensor for certain pathogenic microbes and triggering inflammatory responses including the activation of NF-kB and JNK pathways |
Immunogen | Immunogen Type: Recombinant Protein Immunogen Description: Recombinant protein of human NOD1. |
Other Names | [NOD1; CARD4; CLR7.1; NLRC1] |
Gene, Accession # | [NOD1], Gene ID: 10392, NCBI: NP_006083.1, UniProt: Q9Y239 |
Catalog # | MBS9406832 |
Price | $255 |
Order / More Info | NOD1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |