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Antigenic Specificity | Human TIE-2 |
Clone | [IgG1; tek16] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | Protein G purified |
Size | 0.05 mg |
Concentration | n/a |
Applications | ELISA (EIA), Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The unconjugated monoclonal antibody will detect native human TIE-2/tek in ELISA experiments and on the surface of different human cell types. Tie-1/Tie and Tie-2/Tek are receptor tyrosine kinases with unique structural characteristics including two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains, followed by three fibronectin type III-like repeats in the extracellular region, and a split tyrosine kinase domain in the cytoplasmic region. Tie-2 is involved in vascular stabilization and remodeling. Although less well understood, Tie-1 may also act as an ANG receptor, possibly in complex with Tie-2. Human Tie-2 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18 residue putative signal |
Immunogen | Immunogen: recombinant human soluble TIE-2. Conjugation: Biotin. Preparation: Monoclonal antibodies were produced with the help of BALB/c mice using recombinant human soluble extracellular domain of TIE-2. |
Other Names | [human TIE-2-Biotin (#tek16); Tyrosine kinase with Ig and EGF homology domain-2], [TEK; TEK; TIE2; VMCM; TIE-2; VMCM1; CD202B; TIE2; VMCM; VMCM1; hTIE2] |
Gene, Accession # | [TIE-2], Gene ID: 7010, NCBI: NP_000450.2, UniProt: Q02763 |
Catalog # | MBS690022 |
Price | $345 |
Order / More Info | Human TIE-2 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Reusch et al., Angiogenesis 4:123, 2001 2. Harris et al., Clin Cancer Res. 7 :1992, 2001 3. Partanen J and DJ Dumont (1999) Curr Top Microbiol Immunol 237:159. 4. Takakura N et al, (1998) Immunity 9:677. 5. Procopio W et al, (1999) J Biol Chem 274:30196. 6. Sato et al. (1993) PNAS 90:9355 7.Gale et al., (1999) Gen Dev 13:1055 8. Van Hoof et al, J Proteome Res 9:1610, 2010 |