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Antigenic Specificity | MEK2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 0.05 mg |
Concentration | 1 mg/ml |
Applications | Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | MEK2 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in MAP2K2 gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. |
Immunogen | Immunogen: MEK2 antibody was raised in Rabbit using the peptide sequence around phosphorylation site of threonine 394 (P-G-T(p)-P-T) derived from Human MEK-2 as the immunogen. |
Other Names | [Rabbit MEK2; MEK2; MEK2; MEK 2; MEK2; MEK 2; PRKMK2; MEK-2; Mitogen-Activated Protein Kinase 2; MEK-2; MKK2; Phospho Thr394; MAPKK2] |
Gene, Accession # | [MEK2] |
Catalog # | MBS5309470 |
Price | $295 |
Order / More Info | MEK2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |