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Antigenic Specificity | PHLPP2 (C-term), 1295-1323 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 2 |
Applications | Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This PHLPP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1295-1323 amino acids from the C-terminal region of human PHLPP2. PHLPP2 is a protein phosphatase that specifically mediates dephosphorylation of 'Ser-473' of AKT1. This protein regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decrease cell proliferation. It also controls the phosphorylation of AKT3. |
Immunogen | n/a |
Other Names | [PH domain leucine-rich repeat-containing protein phosphatase 2; PH domain leucine-rich repeat-containing protein phosphatase-like; PHLPP-like; PHLPP2; KIAA0931; PHLPPL] |
Gene, Accession # | [PHLPP2], Gene ID: 23035, NCBI: NP_055835.2, UniProt: Q6ZVD8 |
Catalog # | MBS9207064 |
Price | $165, $370 |
Order / More Info | PHLPP2 (C-term), 1295-1323 Antibody from MYBIOSOURCE INC. |
Product Specific References | Brognard,J., Mol. Cell 25 (6), 917-931 (2007) |