SMURF2 Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | SMURF2 |
| Clone | [1826CT865.51.28] |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1,k |
| Format | unconjugated |
| Size | 0.05 mL, 0.2 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This SMURF2 antibody is generated from a mouse immunized with a recombinant protein of human SMURF2. E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduc |
| Immunogen | n/a |
| Other Names | [E3 ubiquitin-protein ligase SMURF2; hSMURF2; 6.3.2.-; SMAD ubiquitination regulatory factor 2; SMAD-specific E3 ubiquitin-protein ligase 2; SMURF2] |
| Gene, Accession # | [SMURF2], Gene ID: 64750, NCBI: NP_073576.1, UniProt: Q9HAU4 |
| Catalog # | MBS9230986 |
| Price | $165, $370 |
| Order / More Info | SMURF2 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Kavsak P.,et al.Mol. Cell 6:1365-1375 (2000). Lin X.,et al.J. Biol. Chem. 275:36818-36822 (2000). Zhang Y.,et al.Proc. Natl. Acad. Sci. U.S.A. 98:974-979 (2001). Bonni S.,et al.Nat. Cell Biol. 3:587-595 (2001). Di Guglielmo G.M.,et al.Nat. Cell Biol. 5:410-421 (2003). |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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