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Antigenic Specificity | Cathepsin B |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mg |
Concentration | 200 ug/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The purified antibody detects both the proform (37-43 kDa) and the mature form (25 kDa) of Cathepsin B. It reacts with human and mouse and in a lesser extent with rat samples. Cathepsin B is a normal lysosomal cysteine proteinase that is expressed in all cells. It is synthesized as an inactive 43 kDa pro enzyme which, by removal of a 62 amino acid propeptide, is activated to the single chain form of 31 kDa or the two chain form (25 and 5 kDa subunits). Matured cathepsin B is normally localized in the lysosomes where it functions in protein turnover. Cathepsin B is also shown capable of degrading extracellular matrix proteins. Elevated levels of cathepsin B correlate with malignancy suggesting that this enzyme may be a useful prognostic mark |
Immunogen | Immunogen: Cathepsin B antibody was raised in Rabbit using synthetic peptide surrounding amino acid 322 of human Cathepsin B as the immunogen. |
Other Names | [Rabbit Cathepsin B; Cathepsin B; Cathepsin B; Cathepsin-B] |
Gene, Accession # | Gene ID: 1508, NCBI: NP_680093.1, UniProt: P07858 |
Catalog # | MBS5309074 |
Price | $705 |
Order / More Info | Cathepsin B Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |