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Antigenic Specificity | Human p75NTR |
Clone | monoclonal |
Host Species | Mouse |
Reactive Species | human, mouse, rat |
Isotype | IgG |
Format | Protein G purified |
Size | 0.05 mL |
Concentration | 1ug/ul |
Applications | Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Specificity has been confirmed using a number of techniques as described in the reference by Rogers et al (2006). p75NTR was originally discovered as a low affinity nerve growth factor receptor. Later it was found that it was the receptor for all neurotrophins. It mediates signals of neurotrophins for neuronal survival, apoptosis, neurite outgrowth and synaptic plasticity. Recently, it has been revealed that p75NTR is not only acts as the receptor for neurotrophins but also the receptor for many other pathological ligands such as prions, rabies virus and amyloid beta. p75NTR also acts as a co-receptor for NOGO which mediates inhibitory signals of myelin associated protein. p75NTR is highly expressed in a number of non-neuronal |
Immunogen | Immunogen: Extracellular domain of human p75NTR Storage Buffer: PBS, pH 7.4 with 0.02% sodium azide. |
Other Names | [p75 NTR] |
Gene, Accession # | [p75NTR] |
Catalog # | MBS4152677 |
Price | $515 |
Order / More Info | Human p75NTR Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |