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Antigenic Specificity | Bid |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.03 mg, 0.1 mg |
Concentration | 0.5 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Background: Bid, a BH3 domain-containing proapoptotic Bcl-2 family member, is localized in the cytosolic fraction of cells as an inactive precursor. Its active form is generated upon proteolytic cleavage by caspase-8 in the Fas signaling pathway. Cleaved Bid translocates to mitochondria and releases its potent proapoptotic activity, which in turn induces cytochrome c release and mitochondrial damage. The cytochrome c releasing activity of Bid was antagonized by Bcl-2. Mutation in the SH3 domain can diminish the cytochrome c releasing activity. In the animal model studies, Bid-deficient mice are found resistant to the lethal effects of death factor signals relayed thromugh Fas. |
Immunogen | Immunogen: Synthetic peptide surrounding amino acid 45 of mouse Bid |
Other Names | [FP497; MGC42355; MGC15319], [Bid; Bid; AI875481; AU022477; 2700049M22Rik; BID] |
Gene, Accession # | [Bid], Gene ID: 12122, NCBI: NP_031570.2, UniProt: P70444 |
Catalog # | MBS840806 |
Price | $150, $290 |
Order / More Info | Bid Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |