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Antigenic Specificity | DNAJB12 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (PubMed:21150129, PubMed:21148293). Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities. Can also act independently of HSPA8/Hsc70: together with DNAJB14, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers (PubMed:27916661). While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70 (PubMed:2 |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 250-409 of human DNAJB12 (NP 060096.3). |
Other Names | [DJ10] |
Gene, Accession # | [DNAJB12], NCBI: NP_001002762, UniProt: Q9NXW2 |
Catalog # | MBS8549529 |
Price | $280 |
Order / More Info | DNAJB12 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |