Edit |   |
---|---|
Antigenic Specificity | KMT5A |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | biotin conjugate |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative rol |
Immunogen | Immunogen: Recombinant human N-lysine methyltransferase KMT5A protein |
Other Names | [N-lysine methyltransferase KMT5A Curated; H4-K20-HMTase KMT5A; Histone-lysine N-methyltransferase KMT5A (EC:2.1.1.43); Lysine N-methyltransferase 5A; Lysine-spe; KMT5A] |
Gene, Accession # | [KMT5A], Gene ID: 387893, NCBI: NP_065115.3, UniProt: Q9NQR1 |
Catalog # | MBS7043701 |
Price | $160, $235 |
Order / More Info | KMT5A Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |