Phospho-Thr202 Synaptotagmin Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Phospho-Thr202 Synaptotagmin |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Specific for the ~60k - 62k synaptotagmin protein phosphorylated at Thr202. The immunolabeling is completely eliminated by lambda-phosphatase treatment. In some lysates and/or various tissues, additional bands may be seen at ~ 45k, 75k and 150k. Affinity purified rabbit polyclonal antibody. Synaptotagmin is widely regarded as the primary calcium sensor for synaptic vesicle exocytosis (Fernandez-Chacon et al., 2001; Wang et al., 2003). Moreover, recent studies indicate that the protein also plays a key role in endocytosis (Poskanzer et al., 2003). Synaptotagmin can be phosphorylated by multiple protein kinases and this may play a key role in modulation of synaptotagmin's ability to influence both the exocytotic and endocytotic c |
| Immunogen | Antigen: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Thr202 of synaptotagmin. Immunogen Information: Synthetic phospho-peptide corresponding to amino acid residues surrounding Thr202 conjugated to KLH. Immunogen Species: Rat |
| Other Names | [synaptotagmin-1; Synaptotagmin-1; synaptotagmin-1; sytI; synaptotagmin 1; synaptotagmin I; Synaptotagmin I; SytI; p65], [Syt1; Syt1; P65; SytI] |
| Gene, Accession # | [SYT1], Gene ID: 25716, NCBI: NP_001028852.2, UniProt: P21707 |
| Catalog # | MBS502123 |
| Price | $360 |
| Order / More Info | Phospho-Thr202 Synaptotagmin Antibody from MYBIOSOURCE INC. |
| Product Specific References | • Fernandez-Chacon R, Konigstorfer A, Gerber SH, Garcia J, Matos MF, Stevens CF, Brose N, Rizo J, Rosenmund C, Sudhof TC (2001) Synaptotagmin I functions as a calcium regulator of release probability. Nature (London) 410:41-49.• Hilfiker S, Pieribone VA, Nordstedt C, Greengard P, Czernik AJ (1999) Regulation of synaptotagmin I phosphorylation by multiple protein kinases. J Neurochem 73:921-932.• Lee BH, Min X, Heise CJ, Xu BE, Chen S, Shu H, Luby-Phelps K, Goldsmith EJ, Cobb MH (2004) WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding. Mol Cell 15:741-751.• Poskanzer KE, Marek KW, Sweeney ST, Davis GW (2003) Synaptotagmin I is necessary for compensatory synaptic vesicle endocytosis in vivo. Nature (London) 426:559-563.• Wang CT, Lu JC, Bai JH, Chang PY, Martin TFJ, Chapman ER, Jackson MB (2003) Different domains of synaptotagmin control the choice between kiss-and-run and full fusion. Nature (London) 424:943-947. |
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