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Antigenic Specificity | MPYS |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | MPYS is a recently identified plasma membrane tetraspanner that is associated with major histocompatibility complex class II (MHC-II) and mediates its transduction of apoptotic signals. It has also been found to be associated with VISA, a mitochondrial protein that acts as an adaptor in virus-triggered signaling. MPYS also interacts with IRF3 and recruits the kinase TBK1 to the VISA-associated complex, acting as a critical mediator of virus-triggered IRF3 activation and interferon (IFN) expression. It is thought that the binding of nucleic acid to the innate immune protein RIG-I causes complex formation between RIG-I, VISA, and MPYS. This complex then recruits TBK1 to phosphorylate IRF3 which then directly activates IFN transcription. At le |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a 17 amino acid peptide near the carboxy terminus of human MPYS. |
Other Names | [MPYS, Transmembrane protein 173, TMEM173, ERIS, MITA, STING] |
Gene, Accession # | [MPYS], Gene ID: 340061, NCBI: NP_938023 |
Catalog # | MBS9402514 |
Price | $320 |
Order / More Info | MPYS Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |