Edit |   |
---|---|
Antigenic Specificity | Phospho-PAK4/PAK5/PAK6 (S474/S560/S602) |
Clone | monoclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | IgG |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus re |
Immunogen | Immunogen: A synthesized peptide derived from human Phospho-PAK4/PAK5/PAK6 (S474/S560/S602) |
Other Names | [Serine/threonine-protein kinase PAK 4; p21-activated kinase 4; PAK-4; PAK4; KIAA1142] |
Gene, Accession # | [PAK4/PAK5/PAK6], Gene ID: 10298, NCBI: NP_001014831.1, UniProt: O96013 |
Catalog # | MBS7114875 |
Price | $185, $265 |
Order / More Info | Phospho-PAK4/PAK5/PAK6 (S474/S560/S602) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |