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Antigenic Specificity | BACE2 (Center), 336-365 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 2 |
Applications | Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This BACE2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-365 amino acids from the Central region of human BACE2. Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by BACE2. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. |
Immunogen | n/a |
Other Names | [Beta-secretase 2; Aspartic-like protease 56 kDa; Aspartyl protease 1; ASP1; Asp 1; Beta-site amyloid precursor protein cleaving enzyme 2; Beta-site APP cleaving enzyme 2; Down region aspartic protease; DRAP; Memapsin-1; Membrane-associated aspartic protease 1; Theta-secretase; BACE2; AEPLC; ALP56; ASP21] |
Gene, Accession # | [BACE2], Gene ID: 25825, NCBI: NP_036237.2, UniProt: Q9Y5Z0 |
Catalog # | MBS9215320 |
Price | $165, $370 |
Order / More Info | BACE2 (Center), 336-365 Antibody from MYBIOSOURCE INC. |
Product Specific References | Clark, H.F., et al., Genome Res. 13(10):2265-2270 (2003). Basi, G., et al., J. Biol. Chem. 278(34):31512-31520 (2003). Barbiero, L., et al., Exp. Neurol. 182(2):335-345 (2003). Shi, X.P., et al., J. Biol. Chem. 278(23):21286-21294 (2003). Kondoh, K., et al., Breast Cancer Res. Treat. 78(1):37-44 (2003). |