Phospho-IRF-3 (Ser396) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Phospho-IRF-3 (Ser396) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Phospho-IRF-3 (Ser396) antibody detects endogenous levels of IRF-3. Function: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA |
| Immunogen | Immunogen: A synthesized peptide derived from human IRF-3 around the phosphorylation site of Ser396. Subcellular Location: Cytoplasm. Nucleus. Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect. When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm. Tissue Specificity: Expressed constitutively in a variety of tissues. Predicted Cross Reactivity: Pig, Bovine, Horse, Sheep, Dog Similarity: Pig (100%), Bovine (91%), Horse (100% |
| Other Names | [IIAE7; Interferon regulatory factor 3; IRF 3; IRF-3; IRF3; IRF3_HUMAN; MGC94729] |
| Gene, Accession # | [IRF-3], Gene ID: 3661, NCBI: NP_001184051.1, UniProt: Q14653 |
| Catalog # | MBS9600681 |
| Price | $240, $280 |
| Order / More Info | Phospho-IRF-3 (Ser396) Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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