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Antigenic Specificity | ARHGEF18 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein G purified |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). |
Immunogen | Immunogen: Recombinant human Rho guanine nucleotide exchange factor 18 protein |
Other Names | [Rho guanine nucleotide exchange factor 18; 114 kDa Rho-specific guanine nucleotide exchange factor; p114-Rho-GEF; p114RhoGEF; Septin-associated RhoGEF; SA-RhoGEF; ARHGEF18; KIAA0521] |
Gene, Accession # | [ARHGEF18], Gene ID: 23370, NCBI: NP_001124427.1, UniProt: Q6ZSZ5 |
Catalog # | MBS7000288 |
Price | $160, $235 |
Order / More Info | ARHGEF18 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |