USP5 Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | USP5 |
| Clone | [1340CT704.170.140] |
| Host Species | Mouse |
| Reactive Species | human, mouse, rat |
| Isotype | IgG1,kappa |
| Format | purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 0.5 |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This USP5 antibody is generated from a mouse immunized with a recombination protein from the human region of human USP5. Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys- 63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition. |
| Immunogen | n/a |
| Other Names | [Ubiquitin carboxyl-terminal hydrolase 5; Deubiquitinating enzyme 5; Isopeptidase T; Ubiquitin thioesterase 5; Ubiquitin-specific-processing protease 5; USP5; ISOT] |
| Gene, Accession # | [USP5], Gene ID: 8078, NCBI: NP_001092006.1, UniProt: P45974 |
| Catalog # | MBS9200562 |
| Price | $165, $370 |
| Order / More Info | USP5 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Falquet L.,et al.FEBS Lett. 376:233-237(1995). Ansari-Lari M.A.,et al.Genome Res. 6:314-326(1996). Ansari-Lari M.A.,et al.Genome Res. 7:268-280(1997). Tashayev V.L.,et al.Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases. Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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