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Antigenic Specificity | Cullin 2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total Cullin 2 protein. Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 By similarity. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypox |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthesized peptide derived from human Cullin 2. |
Other Names | [Cullin-2; CUL-2] |
Gene, Accession # | Gene ID: 8453, NCBI: NP_001185706.1, UniProt: Q13617 |
Catalog # | MBS9412061 |
Price | $200, $255 |
Order / More Info | Cullin 2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |