Phospho-MTOR-S2448 Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | Phospho-MTOR-S2448 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The mammalian target of rapamycin (mTOR, FRAP, RAFT) is a Ser/Thr protein kinase (1-3) that functions as an ATP and amino acid sensor to balance nutrient availability and cell growth (4, 5). When sufficient nutrients are available, mTOR responds to a phosphatidic acid-mediated signal to transmit a positive signal to p70 S6 kinase and participate in the inactivation of the eIF4E inhibitor, 4E-BP1 (6). These events result in the translation of specific mRNA subpopulations. mTOR is phosphorylated at Ser2448 via the PI3 kinase/Akt signaling pathway and autophosphorylated at Ser2481 (7, 8). mTOR plays a key role in cell growth and homeostasis and may be abnormally regulated in tumors. For these reasons, mTOR is currently under investigation as a |
| Immunogen | Immunogen: A phospho specific peptide corresponding to residues surrounding serine 2448of human mTOR/FRAP Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [MTOR; FLJ44809; FRAP; FRAP1; FRAP2; RAFT1; RAPT1] |
| Gene, Accession # | [MTOR-S2448], Gene ID: 2475, NCBI: NP_004949.1, UniProt: P42345 |
| Catalog # | MBS8527459 |
| Price | $310 |
| Order / More Info | Phospho-MTOR-S2448 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Sabers, C.J. et al. (1995) J Biol Chem 270, 815-22. 2. Brown, E.J. et al. (1994) Nature 369, 756-8. 3. Sabatini, D.M. et al. (1994) Cell 78, 35-43. 4. Gingras, A.C. et al. (2001) Genes Dev 15, 807-26. 5. Dennis, P.B. et al. (2001) Science 294, 1102-5. 6. Fang, Y. et al. (2001) Science 294, 1942-5. 7. Nave, B.T. et al. (1999) Biochem J 344 Pt 2, 427-31. 8. Peterson, R.T. et al. (2000) J Biol Chem 275, 7416-23. 9. Huang, S. and Houghton, P.J. (2003) Curr Opin Pharmacol 3, 371-7. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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