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Antigenic Specificity | TLR4 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responses (1-3). TLRs recognize conserved motifs found in various pathogens and mediate defense responses. Triggering of the TLR pathway leads to the activation of NF-kappaB and subsequent regulation of immune and inflammatory genes. The TLRs and members of the IL-1 receptor family share a conserved stretch of approximately 200 amino acids known as the TIR domain. Upon activation, TLRs associate with a number of cytoplasmic adaptor proteins containing TIR domains including MyD88 (myeloid differentiation factor), MAL/TIRAP (MyD88-adaptor-like/TIR-associated protein), TRIF (Toll-receptor-associated ac |
Immunogen | Immunogen: Fusion protein to Human TLR4 |
Other Names | [TLR4 Rabbit pab], [TLR4; ARMD10; CD284; TOLL; hToll] |
Gene, Accession # | Gene ID: 7099, NCBI: NP_003257.1, UniProt: O00206 |
Catalog # | MBS125491 |
Price | $200, $275, $430 |
Order / More Info | TLR4 Antibody from MYBIOSOURCE INC. |
Product Specific References | Akira, S. (2003) J Biol Chem 278, 38105-8.Rock, F.L. et al. (1998) Proc. Natl. Acad. Sci. USA 95, 588-593.Poltorak, A. et al. (1998) Science 282, 2085-2088.Chow, J.C. et al. (1999) J. Biol. Chem. 274, 10689-10692.Hoshino, K. et al. (1999) J. Immunol. 162, 3749-3752. |