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Antigenic Specificity | Gzma |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | mouse |
Isotype | n/a |
Format | fluorescein (FITC) conjugate |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA (By similarity). |
Immunogen | Immunogen: Recombinant mouse Granzyme A protein Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-5515 |
Other Names | [Granzyme A (EC:3.4.21.78); Gzma; Ctla-3; Ctla3; Mtsp-1; Autocrine thymic lymphoma granzyme-like serine protease; CTLA-3; Fragmentin-1; T cell-specific serine protease 1; TSP-1], [Gzma; Gzma; Hf; SE1; TSP1; Ctla3; TSP-1; Ctla-3; AW494114; Ctla-3; Ctla3; Mtsp-1; TSP-1] |
Gene, Accession # | [Gzma], Gene ID: 14938, NCBI: NP_034500.1, UniProt: P11032 |
Catalog # | MBS1491755 |
Price | $160, $235 |
Order / More Info | Gzma Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |