VEGFR-2 Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | VEGFR-2 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, dog |
| Isotype | n/a |
| Format | epitope affinity purified |
| Size | 0.1 mg |
| Concentration | Size: 100 ug/200 ul |
| Applications | ELISA, Western Blot, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This antibody recognizes ~200 and ~240 kDa of human VEGFR-2 protein. This antibody also reacts with mouse. The other species are not tested. Vascular endothelial growth factor receptor-2 (VEGFR-2), also known as CD309 antigen, the earliest known marker for vascular endothelia cells, is essential in vasculogenesis and angiogenesis. Binding of the dimeric VEGF-A to the extracellular domains of two monomeric receptors induces dimerization and activation of tyrosine kinase at tyrosine residues Y951, Y1054 and Y1059 in the kinase domain serve as positive regulatory sites. Phosphorylation at Y951 of the kinase insert is related to the migration of endothelial cells for tumor vascularization and growth. |
| Immunogen | Antigen Preparation: A synthetic peptide corresponding to the extracellular domain of human VEGFR-2 protein. This sequence is identical within human, mouse and dog. |
| Other Names | [Rabbit VEGFR-2; Vascular endothelial growth factor receptor 2 (VEGFR-2); KDR/ Flk-1; CD309 antigen], [KDR; KDR; FLK1; CD309; VEGFR; VEGFR2; FLK1] |
| Gene, Accession # | [VEGFR-2 (CD309)], Gene ID: 3791, NCBI: NP_002244.1, UniProt: P35968 |
| Catalog # | MBS462167 |
| Price | $245 |
| Order / More Info | VEGFR-2 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Taro Matsumoto, et al. VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis. The EMBO Journal (2005) 24, 2342-2353. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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