PHLDA3 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | PHLDA3 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: PHLDA3 antibody detects endogenous levels of total PHLDA3. Function: p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor.Similarity: The PH domain binds phosphoinositides with a broad specificity. It competes with the PH domain of AKT1 and directly interferes with AKT1 binding to phosphatidylinositol 4, 5-bisphosphate (PIP2) and phosphatidylinositol 3, 4, 5-trisphosphate (PIP3), prev |
| Immunogen | Immunogen: A synthesized peptide Subcellular Location: Cytoplasm. Membrane. Tissue Specificity: Widely expressed with lowest expression in liver and spleen. Predicted Cross Reactivity: Pig, Rabbit Similarity: Pig (90%), Rabbit (100%) |
| Other Names | [PHLA3_HUMAN; PHLDA 3; phlda3; Pleckstrin homology like domain family A member 2; Pleckstrin homology like domain family A member 3; Pleckstrin homology-like domain family A member 3; TDAG51/Ipl homolog 1; TDAG51/Ipl homologue 1; TIH 1; TIH1] |
| Gene, Accession # | [PHLDA3], Gene ID: 23612, NCBI: NP_036528.1, UniProt: Q9Y5J5 |
| Catalog # | MBS9603904 |
| Price | $240, $280 |
| Order / More Info | PHLDA3 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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