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Antigenic Specificity | CUL2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein G purified |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF). |
Immunogen | Immunogen: Recombinant Human Cullin-2 protein (591-742AA) |
Other Names | [Cullin-2; CUL-2; CUL2] |
Gene, Accession # | [CUL2], Gene ID: 8453, NCBI: NP_001185706.1, UniProt: Q13617 |
Catalog # | MBS7050281 |
Price | $160, $235 |
Order / More Info | CUL2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |