Edit |   |
---|---|
Antigenic Specificity | D6/ACKR2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Direct ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Description: Rabbit IgG polyclonal antibody for D6/ACKR2 detection. Tested with WB, IHC-P, Direct ELISA in Human.Background: This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor app |
Immunogen | Immunogen: E Coli-derived human D6/ACKR2 recombinant protein (Position: M138-A384). |
Other Names | [Atypical chemokine receptor 2; C-C chemokine receptor D6; Chemokine receptor CCR-10; Chemokine receptor CCR-9; Chemokine-binding protein 2; Chemokine-binding protein D6; ACKR2; CCBP2; CCR10; CMKBR9; D6] |
Gene, Accession # | [ACKR2], Gene ID: 1238, NCBI: NP_001287.2, UniProt: O00590 |
Catalog # | MBS1751491 |
Price | $315 |
Order / More Info | D6/ACKR2 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Jamieson, T., Cook, D. N., Nibbs, R. J. B., Rot, A., Nixon, C., Mclean, P., Alcami, A., Lira, S. A., Wiekowski, M., Graham, G. J. The chemokine receptor D6 limits the inflammatory response in vivo. Nature Immun. 6: 403-411, 2005. 2. Nibbs, R. J. B., Gilchrist, D. S., King, V., Ferra, A., Forrow, S., Hunter, K. D., Graham, G. J. The atypical chemokine receptor D6 suppresses the development of chemically induced skin tumors. J. Clin. Invest. 117: 1884-1892, 2007. |