EPCR, Human Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | EPCR, Human |
| Clone | RCR-252 |
| Host Species | Rat |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | fluorescein (FITC) conjugate |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Flow Cytomery(FC/FACS), FS, Immunofluorescence (IF), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Product Description: The monoclonal antibody RCR-252 recognizes human endothelial protein C receptor (EPCR), a highly glycosylated type I transmembrane protein of 221-amino-acids. These amino acids comprise an extracellular domain, a 25-aa transmembrane domain, and a short (3 aa) intracytoplasmic sequence coding for an ~46 kDa protein. Deglycosylation will reduce the protein mass to 25 kDa. EPCR is expressed strongly on the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney. EPCR is the receptor for protein C, a key player in the anticoagulation pathway. The protein C anticoagulant pathway serves as a major |
| Immunogen | Immunogen: Human EPCR-positive RE-1 cells |
| Other Names | [Activated protein C receptor, CD201, Endothelial cell protein C receptor], [PROCR; PROCR; CCCA; EPCR; CCD41; EPCR; APC receptor] |
| Gene, Accession # | [EPCR], Gene ID: 10544, NCBI: NP_006395.2 |
| Catalog # | MBS584002 |
| Price | $785 |
| Order / More Info | EPCR, Human Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Ye, X et al; The endothelial cell protein C receptor (EPCR) functions as a primary receptor for protein C activation on endothelial cells in arteries, veins, and capillaries. Biochem Biophys Res Commun 1999, 259: 671 2. Doemoetoer, E et al; Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1. Blood 2003, 101: 4797 3. Sturn, D et al; Expression and function of the endothelial protein C receptor in human neutrophils. Blood 2003, 102: 1499 4. Finigan, J et al; Activated protein C mediates novel lung endothelial barriere enhancement. J Biol Chem 2005, 280: 17286 5. Bae J et al; Receptors of the protein C activation and activated protein C signaling pathways are colocalized in lipid rafts of endothelial cells. PNAS 2006, 104: 2867 |
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MYBIOSOURCE INC.
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