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Antigenic Specificity | IRF9 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 113-255 of human IRF9 (NP 006075.3). |
Other Names | [p48; IRF-9; ISGF3; ISGF3G] |
Gene, Accession # | [IRF9], Gene ID: 10379, NCBI: Q00978.1, UniProt: Q00978 |
Catalog # | MBS8544172 |
Price | $280 |
Order / More Info | IRF9 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |