Edit |   |
---|---|
Antigenic Specificity | DNAJC3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peroxidase (HRP) conjugate |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity. |
Immunogen | Immunogen: Recombinant human DnaJ homolog subfamily C member 3 protein |
Other Names | [DnaJ homolog subfamily C member 3; Endoplasmic reticulum DNA J domain-containing protein 6; ER-resident protein ERdj6; ERdj6; Interferon-induced; double-; DNAJC3; P58IPK; PRKRI] |
Gene, Accession # | [DNAJC3], Gene ID: 5611, NCBI: NP_006251.1, UniProt: Q13217 |
Catalog # | MBS7044259 |
Price | $160, $235 |
Order / More Info | DNAJC3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |