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Antigenic Specificity | IKBKB |
Clone | [10A2] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | ascites |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | IKBKB(Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, also called IKK2/IKKB), is a member of the IKK complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK-beta has been shown to activate NF-kB and phosphorylate IKB-alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK-beta is essential for activation of IKK by TNF and IL1. Once activated, IKK-beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK-beta activity can also be regulated by MEKK-1. |
Immunogen | Immunogen: Purified recombinant fragment of IKBKB expressed in E. Coli. |
Other Names | [inhibitor of nuclear factor kappa-B kinase subunit beta isoform 2; Inhibitor of nuclear factor kappa-B kinase subunit beta; inhibitor of nuclear factor kappa-B kinase subunit beta; inhibitor of nuclear factor kappa B kinase subunit beta; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta] |
Gene, Accession # | [IKBKB], Gene ID: 3551, NCBI: NP_001177649.1, UniProt: O14920 |
Catalog # | MBS8538336 |
Price | $280 |
Order / More Info | IKBKB Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |