Beta-Defensin-3 (HBD-3/MBD-3) Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | Beta-Defensin-3 (HBD-3/MBD-3) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | unconjugated |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | ELISA (EIA), Radioimmunoassay (RIA), Western Blot (WB), Immunohistochemistry (IHC) (Not established) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The peptide sequences of HBD-3/MBD-3 used for immunisation contain very little consensus aa with any of the other human or mouse defensins. Human defensins are Cys-rich antimicrobial peptides which specifically react against Gram-negative bacteria. Originally defensins were isolated from hemolysates, but they can also be found on the cell surface of epithelia of the urogenital tract, lung, and trachea. In leukocytes defensins are stored in granules being released into phagolysosomes for the destruction of incorporated micro-organisms. Amino acid sequences of alpha-defensins 1-4 (HNP1-4) and beta-Defensins 1-4 (HBD1-4) are known. Mature Human Beta-Defensin-3 (HBD-3) shares app. 22% aa sequence homology with HBD-1. beta-defensin-3 of human an |
| Immunogen | Immunogen: Mixture of synthetic peptides 15 aa near C-terminus of the mature HBD-3 (LPKEEQIGKCSTRGR) and 13 aa of N-terminal MBD-3, coupled to KLH for immunisation of rabbits |
| Other Names | n/a |
| Gene, Accession # | [HBD-3/MBD-3] |
| Catalog # | MBS397186 |
| Price | $950 |
| Order / More Info | Beta-Defensin-3 (HBD-3/MBD-3) Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Harder J., Bartels J., Christophers E., and J.-M. Schroder (1997) Antibacterial peptide specific for Gram-negative Bacteria/also effective for Candida albicans. Nature 387; 861ff. 2. Bals R., Wang X., Meegalla R. L., Wattler S., et al. (1999) Mouse beta-Defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs. Infection and Immunity 67(7); 3542-3547. 3. Jia H.P., Schutte B.C., Schudy A., Linzmeier R., et al. (2001) Discovery of new human beta-defensins using a genomics-based approach. Gene 263(1-2);211-218. 4. Garcia J.R., Jaumann F., Schulz S., Krause A., et al. (2001) Identification of a novel multifunctional beta-defensin (human beta-defensin 3) with specific antimicrobial activity. Its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattraction. Cell Tissue Res. 306(2); 257-264. 5. Harder J., Bartels J., Christophers E., and J.-M. Schroder (2001) Isolation and characterization of human beta-defensin-3, a novel human inducible peptide antibiotic. J. Biol. Chem. 276(8); 5707-5713. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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