Edit |   |
Antigenic Specificity | AFP (Alpha Fetoprotein) (Hepatocellular/Germ Cell Tumor Marker) |
Clone | [MBS-12] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1, kappa |
Format | unconjugated |
Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: It recognizes an oncofetal glycoprotein with a single chain of 70kDa, which is identified as alpha fetoprotein (AFP). This MAb is highly specific to AFP and shows no cross-reaction with other oncofetal antigens or serum albumin. The yolk sac and the liver produce AFP during fetal life. AFP expression in adults is often associated with hepatoma or teratoma. However, hereditary persistence of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the AFP and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. AFP is found in monomeric as well as dimeric and trimeric forms, and binds copper, nick |
Immunogen | Immunogen: Recombinant full-length human Alpha fetoprotein |
Other Names | [Alpha fetoglobulin; FETA; HPAFP], [AFP; AFP; AFPD; FETA; HPAFP; HPAFP] |
Gene, Accession # | [AFP], Gene ID: 174, NCBI: NP_001125.1, UniProt: P02771 |
Catalog # | MBS438910 |
Price | $190, $340, $340 |
Order / More Info | AFP (Alpha Fetoprotein) (Hepatocellular/Germ Cell Tumor Marker) Antibody from MYBIOSOURCE INC. |
Product Specific References | Stefanova, I., Horejs-, V., Kristofov-, H., Angelisov-, P., Zizkovsky, V. and Hilgert, I. 1988. Monoclonal antibodies against human alpha-fetoprotein. Exploitation of an unusual calcium-dependent interaction with the antigen for analytical and preparative purposes. J. Immunol. Methods 111: 67-73. Lafuste, P., et al. 2002. alpha-fetoprotein gene expression in early and full-term human trophoblast. Placenta 23: 600-612 |