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Antigenic Specificity | MUTYH |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Base excision repair (BER) proteins catalyze the removal of incorrect or damaged bases, including oxidized bases, from DNA. N-glycosylases specific to a given lesion remove the incorrect base as the first step in BER. MYH is the mammalian ortholog of E. coli MutY, a DNA glycosylase that catalyzes the removal of 8-oxoG:A mismatches (1). Several MYH isoforms have been detected in human cells localizing to either the nucleus or the mitochondria (2). MYH interacts with DNA repair proteins and localizes to DNA damage foci after oxidative damage (3). Research studies have shown that mutations in the corresponding MYH gene are associated with human gastric (4) and colorectal (5-7) cancers. |
Immunogen | Immunogen: Recombinant protein of human MUTYH Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Other Names | [MGC4416; MYH] |
Gene, Accession # | [MUTYH], Gene ID: 4595, NCBI: NP_001041636.1, UniProt: Q9UIF7 |
Catalog # | MBS8503616 |
Price | $310 |
Order / More Info | MUTYH Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Slupska, M.M. et al. (1996) J Bacteriol 178, 3885-92. 2. Ohtsubo, T. et al. (2000) Nucleic Acids Res 28, 1355-64. 3. Shi, G. et al. (2006) Biochem J 400, 53-62. 4. Kobayashi, K. et al. (2008) Anticancer Res 28, 215-21. 5. Bai, H. et al. (2007) Cancer Lett 250, 74-81. 6. Pope, M.A. et al. (2005) DNA Repair (Amst) 4, 315-25. 7. Wooden, S.H. et al. (2004) Cancer Lett 205, 89-95. |