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Antigenic Specificity | B-raf |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | B-raf belongs to the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. The Ras/Raf/MEK/ERK and Ras/PI3K/PTEN/Akt pathways interact with each other to regulate growth and in some cases tumorigenesis. Mutations in B-raf have been associated with several cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung, leading to speculation on the possibility of B-raf as a therapeutic target for treating cancers. Mutations in this gene have also been associated with cardiofaciocutaneous syndrome (CFCS), a disease character |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against an 18 amino acid peptide near the center of human B-raf. |
Other Names | [v-raf murine sarcoma viral oncogene homolog B1, proto-oncogene B-raf, p94] |
Gene, Accession # | [B-raf], Gene ID: 673, NCBI: NP_004324.2, UniProt: P15056 |
Catalog # | MBS9403583 |
Price | $320 |
Order / More Info | B-raf Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |