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Antigenic Specificity | GRK 2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.03 mL, 0.1 mL, 0.2 mL |
Concentration | 1 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) Paraffin, ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: GRK 2 Polyclonal Antibody detects endogenous levels of GRK 2 protein. Beta-adrenergic receptor kinase 1 phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. Beta-adrenergic receptor kinase 1 is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. |
Immunogen | Immunogen: Synthesized peptide derived from the C-terminal region of human GRK 2 at AA range: 570-650 |
Other Names | [Rabbit GRK 2; ADRBK1; BARK; BARK1; GRK2; Beta-adrenergic receptor kinase 1; Beta-ARK-1; G-protein coupled receptor kinase 2] |
Gene, Accession # | [GRK2], Gene ID: 156, NCBI: NP_001610.2, UniProt: P25098 |
Catalog # | MBS9702181 |
Price | $130, $220, $325 |
Order / More Info | GRK 2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |