Description | Specificity: Mouse heat stable antigen (HSA); Mr 35^-45 kDa. CD24, also known as heat stable antigen, is a phosphatidylinositol^-linked cell surface glycoprotein that is expressed at all stages of B cell development and on most thymocytes.^1^-3 The absence of expression from mature T cells is closely associated with their maturation from CD4^+CD8^+CD24^+ thymocytes to either CD4^+CD8^-CD24^- or CD4^-CD8^+CD24^- T cells. CD24 is also present on mouse granulocytes, monocytes, Langerhans cells and erythrocytes. ^4^-6 Its ligand is P^-selectin (CD62P). ^7 CD24 may play a role in regulation of B cell proliferation and differentiation, and it has been proposed that heat stable antigen promotes homotypic adhesion between B lymphocytes. ^1^-3 The m |
Product Specific References | 1. Bruce, J., F.W. Symington, T.J. McKearn, and J. Sprent. 1981. J. Immunol. 127:2496.2. Alterman, L.A., I.N. Crispe, and C. Kinnon. 1990. Eur. J. Immunol. 20:1597.3. Davidson, W.F., T.M. Chused, and H.C. Morse. 1981. Immunogenetics 13:421.4. Rougon, G., L.A. Alterman, K. Dennis, X.J. Guo, and C. Kinnon. 1991. Eur. J. Immunol. 21:1397.5. Wilson, A., L.M. Day, R. Scollay, and K. Shortman. 1984. Immnol. Rev. 82:79.6. Shortman, K., A. Wilson, M. Egerton, M. Pearse, and R. Scollay. 1988. Cell. Immunol. 117:312.7. Aigner, S., M. Ruppert, M. Hubbe, M. Sammar, Z. Sthoeger, E. C. Butcher, D. Vestweber, and P. Altevogt. 1995. International Immunology 7:1557.8. Kearney, J.F. Personal communication. |