DNAJB6 Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityDNAJB6
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman, mouse, rat
Isotypen/a
Formatpeptide affinity purified
Size0.1 mL, 0.2 mL
Concentration1mg/ml
ApplicationsWestern Blot (WB), ELISA (EIA)
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DescriptionSpecificity: DNAJB6 antibody detects endogenous levels of total DNAJB6. Function: Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity.Subunit Structure: Homooligomer. Interacts with BAG3, HSPB8 and STUB1. Interacts with ALKBH1 (By similarity). Interacts with HSP70, KRT18 and PTTG. Iso
ImmunogenImmunogen: A synthesized peptide Subcellular Location: Cytoplasm, Perinuclear Region. Nucleus. Cytoplasm, Myofibril, Sarcomere, Z Line. Tissue Specificity: Widely expressed. Highest levels in testis and brain, and lower levels in heart, spleen, intestine, ovary, placenta, lung, kidney, pancreas, thymus, prostate, skeletal muscle, liver and leukocytes. In testis, expressed in germ cells in the earlier stages of differentiation pathway as well as in spermatids. In brain, expressed at a higher leve
Other Names[DJ4; DnaJ; DnaJ (Hsp40) homolog subfamily B member 6; DNAJ B6; DnaJ homolog subfamily B member 6; DnaJ like 2 protein; DNAJB6; DNJB6_HUMAN; Heat shock protein J2; HHDJ1; HSJ-2; HSJ2; LGMD1E; MRJ; MSJ-1; MSJ1]
Gene, Accession #[DNAJB6], Gene ID: 10049, NCBI: NP_005485.1, UniProt: O75190
Catalog #MBS9604003
Price$240, $280
Order / More InfoDNAJB6 Antibody from MYBIOSOURCE INC.
Product Specific Referencesn/a
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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