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Antigenic Specificity | NPRL2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total NPRL2 protein. Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at 'Tyr-9', 'Tyr-373' and 'Tyr-376' residues. May act as a tumor suppressor. Suppresses cell growth and enhances sensitivity to various anticancer drugs. As a component of the GATOR1 complex, inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. |
Immunogen | Immunogen Type: Recombinant Protein Immunogen Description: Recombinant protein of human NPRL2. |
Other Names | [NPR2; NPR2L; TUSC4] |
Gene, Accession # | [NPRL2], Gene ID: 10641, NCBI: NP_006536.3, UniProt: Q8WTW4 |
Catalog # | MBS9407221 |
Price | $255 |
Order / More Info | NPRL2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |