Phospho-Ser847 CtIP Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Phospho-Ser847 CtIP |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | avian, bovine, dog, chicken, goat, guinea pig, mouse, nonhuman primate, sheep |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Specific for endogenous levels of the ~100 kDa CtIP protein phosphorylated at Thr847. Immunolabeling is completely eliminated by treatment with lambda-Ptase. CtIP, C-terminal binding protein-interacting protein, is a DNA endonuclease activated by double stranded breaks (DSBs). DSB repairs can be performed by either one of two mechanisms; non-homologous end joining (NHEJ) or homologous recombination (HR). NHEJ is the predominant DSB repair pathway throughout the entire cell cycle, most importantly in the G1 phase (Rothkamm et al, 2003); while HR is important for repairing DSBs in S and G2 phases (Beucher et al, 2009). CtIP controls DSB resection; an event that only occurs in HR during G2-phase. Phosphorylation of Thr847 dictates |
| Immunogen | Immunogen Species: Human. Immunogen Information: Synthetic phospho-peptide corresponding to amino acid residues surrounding Thr847 conjugated to KLH |
| Other Names | [DNA endonuclease RBBP8 isoform a; DNA endonuclease RBBP8; DNA endonuclease RBBP8; RB binding protein 8, endonuclease; CtBP-interacting protein; CtIP; Retinoblastoma-binding protein 8; RBBP-8; Retinoblastoma-interacting protein and myosin-like; RIM; Sporulation in the absence of SPO11 protein 2 homolog; SAE2], [RBBP8] |
| Gene, Accession # | [CtIP], Gene ID: 5932, NCBI: NP_002885.1, UniProt: Q99708 |
| Catalog # | MBS500069 |
| Price | $360 |
| Order / More Info | Phospho-Ser847 CtIP Antibody from MYBIOSOURCE INC. |
| Product Specific References | Rothkamm K, Kruger I, Thompson LH, Lobrich M (2003) Pathways of DNA double-strand break repair during the mammalian cell cycle. Mol Cell Biol., 23, 5706-5715.Beucher A, Birraux J, tchouandong L, Baron O, Shibata A, Conrad S, Goodarzi AA, Krempler A, Jeggo PA, Lobrich M (2009) ATM and Artemis promote homologous recombination of radiation-inducted DNA double-strand breaks in G2. EMBO J., 28, 3413-3427.Huertas P, Jackson SP (2008) Human CtIP Mediates Cell Cycle Control of DNA End Resection and Double Strand Break Repair. J. Biol. Chem, 284: 9558-9565. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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