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Antigenic Specificity | TIRAP |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.06 mL, 0.12 mL, 0.2 mL |
Concentration | 1mg/mL |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. |
Immunogen | Immunogen: Recombinant protein of human TIRAP Observed Molecular Weight: 23kDa |
Other Names | [Mal; wyatt; BACTS1; MyD88-2] |
Gene, Accession # | [TIRAP], Gene ID: 114609, NCBI: NP_683708.1 |
Catalog # | MBS2527814 |
Price | $150, $225, $360 |
Order / More Info | TIRAP Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |