DOG1, 904-986 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | DOG1, 904-986 |
| Clone | [DOG1.1] |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: DOG1. This antibody recognizes human DOG1. DOG1 (Discovered on GIST1), also known as TMEM16A and ANO1, has emerged in recent years as a promising biomarker for gastrointestinal stromal tumors (GIST). It was originally discovered through microarray expression profiling analysis as a gene that is highly expressed in GIST, and subsequent immunohistochemical studies have shown its use in its diagnosis. DOG1 antibodies are more sensitive than KIT antibodies in detecting tumors of gastric origin, tumors with epithelioid morphology, and tumors harboring PDGFRA mutation. DOG1 immunoreactivity is rarely observed in other mesenchymal and nonmesenchymal tumor types. These results support the use of DOG1 as a biomarker for GIST. |
| Immunogen | Antigen: Synthetic peptide corresponding to aa 904-986 of human DOG1 (accession no. Q5XXA6). Preservative: None. Available on request. |
| Other Names | n/a |
| Gene, Accession # | [DOG1] |
| Catalog # | MBS190561 |
| Price | $365 |
| Order / More Info | DOG1, 904-986 Antibody from MYBIOSOURCE INC. |
| Product Specific References | • Espinosa I et al. 2008 Am J Surg Pathol 32: 210-218. Lee CH et al. 2010 Adv Anat Pathol 17: 222-232. |
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MYBIOSOURCE INC.
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