Edit |   |
---|---|
Antigenic Specificity | CUL4B |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: CUL4B antibody detects endogenous levels of total CUL4B. Function: Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin b |
Immunogen | Immunogen: A synthesized peptide derived from human CUL4B Subcellular Location: Nucleus. |
Other Names | [CUL 4B; CUL-4B; CUL4B; CUL4B_HUMAN; Cullin-4B; DKFZp686F1470; KIAA0695; MRXHF2; MRXSC; SFM2] |
Gene, Accession # | [CUL4B], Gene ID: 8450, NCBI: NP_001073341.1, UniProt: Q13620 |
Catalog # | MBS9608397 |
Price | $240, $280 |
Order / More Info | CUL4B Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |