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Antigenic Specificity | HLA-DQA1 (N-term) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 0.376 |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This HLA-DQA1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 58-90 amino acids from the N-terminal region of human HLA-DQA1. Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for thi |
Immunogen | n/a |
Other Names | [HLA class II histocompatibility antigen; DQ alpha 1 chain; DC-1 alpha chain; DC-alpha; HLA-DCA; MHC class II DQA1; HLA-DQA1] |
Gene, Accession # | [HLA-DQA1], Gene ID: 3117, NCBI: NP_002113.2, UniProt: P01909 |
Catalog # | MBS9202842 |
Price | $165, $370 |
Order / More Info | HLA-DQA1 (N-term) Antibody from MYBIOSOURCE INC. |
Product Specific References | Chang H.-C.,et al.Nature 305:813-815(1983). Schenning L.,et al.EMBO J. 3:447-452(1984). Auffray C.,et al.Nature 308:327-333(1984). Schiffenbauer J.,et al.J. Immunol. 139:228-233(1987). Ellis M.C.,et al.Immunogenetics 46:410-417(1997). |