PUMA Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | PUMA |
| Clone | [10D4G7] |
| Host Species | Mouse |
| Reactive Species | n/a |
| Isotype | n/a |
| Format | immunoaffinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | ELISA (EIA), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMAa and PUMAb. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis. |
| Immunogen | Immunogen Type: Recombinant protein Immunogen Description: Recombinant protein corresponding to amino acids 76 - 170 of human PUMA-alpha. |
| Other Names | [PUMA (10D4G7), p53 upregulated modulator of apoptosis, bbc3, Bcl-2 binding component 3] |
| Gene, Accession # | [PUMA], Gene ID: 27113, NCBI: NP_001120712.1, UniProt: Q9BXH1 |
| Catalog # | MBS9400082 |
| Price | $320 |
| Order / More Info | PUMA Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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