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Antigenic Specificity | RRP8 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.1 mL |
Concentration | 1.4 mg/mL |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total RRP8 protein. Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+/ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown. |
Immunogen | Immunogen: Fusion protein of human RRP8 Immunogen Type: Peptide |
Other Names | [NML; KIAA0409] |
Gene, Accession # | [RRP8], Gene ID: 23378, NCBI: NP_056139.1, UniProt: O43159 |
Catalog # | MBS9430728 |
Price | $255 |
Order / More Info | RRP8 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |