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Antigenic Specificity | IST1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein G purified |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129479, PubMed:19129480). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888). |
Immunogen | Immunogen: Recombinant Human IST1 homolog protein (172-284AA) |
Other Names | [IST1 homolog; hIST1; Putative MAPK-activating protein PM28; IST1; KIAA0174] |
Gene, Accession # | [IST1], Gene ID: 9798, NCBI: NP_001257904.1, UniProt: P53990 |
Catalog # | MBS7107939 |
Price | $160, $235 |
Order / More Info | IST1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |