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Antigenic Specificity | Phospho-MAPKAPK5 (Ser354) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, ratpredicted: porcine, zebrafish, bovine, horse, sheep, rabbit, dog, chicken, Xenopus |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Peptide ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Phospho-MAPKAPK5 (Ser354) Antibody detects endogenous levels of MAPKAPK5 only when phosphorylated at Ser354. Description: Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a n |
Immunogen | Immunogen: A synthesized peptide derived from human MAPKAPK5 around the phosphorylation site of Ser354. Tissue Specificity: Expressed ubiquitously. |
Other Names | [MAP kinase-activated protein kinase 5; MAPK-activated protein kinase 5; MAPK5_HUMAN; MAPKAP kinase 5; MAPKAPK-5; MAPKAPK5; Mitogen activated protein kinase activated protein kinase 5; p38-regulated/activated protein kinase; PRAK] |
Gene, Accession # | [MAPKAPK5], Gene ID: 8550, NCBI: NP_003659.2, UniProt: Q8IW41 |
Catalog # | MBS9610780 |
Price | $225, $280, $340 |
Order / More Info | Phospho-MAPKAPK5 (Ser354) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |